Synthesis of 2-aminoaryl-5-substituted-1, 3, 4-thiadiazoles in a thermal 1, 3-dipolar cycloaddition reaction

…, Z Zwolska, E Augustynowicz-Kopeć

Index: Gobis, Katarzyna; Foks, Henryk; Zwolska, Zofia; Augustynowicz-Kopec, Ewa Phosphorus, Sulfur and Silicon and the Related Elements, 2005 , vol. 180, # 12 p. 2653 - 2666

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Citation Number: 4

Abstract

The preparation of a series of new 2-aminoaryl-1, 3, 4-thiadiazoles substituted with methylsulfanyl, methansulfinyl, or amine in the 5-position is described in this article. The compounds were obtained from N-hydroxyimidoyl chlorides and methyl dithiocarbazinate or 4-substituted thiosemicarbazides in a thermal 1, 3-dipolar cycloaddition reaction. The new derivatives were tested for their activity against Mycobacterium tuberculosis.