Enantioselective hydrolysis of 3-hydroxy-3-methylalkanoic acid esters with pig liver esterase

…, YJ Barber, TJ Scallen, CJ Morrow

Index: Wilson, William K.; Baca, Shawn B.; Barber, Yolanda J.; Scallen, Terence J.; Morrow, Cary J. Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 3960 - 3966

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Citation Number: 48

Abstract

Pig liver esterase has been shown to stereoselectively hydrolyze the R enantiomer of several chiral 3-hydroxy-3-methylhoic acid eaters of the form RC (Me)(OH) CH, COOR', where R= Et, CH&HCH2, Me (CH+,(Me0) 2CHCH2, and PhCH20CH2CH2 and R'= Me or Et. The unhydrolyzed ester and the reesterified carboxylic acid were analyzed for enantiomeric purity by NMR using the chiral shift reagent Eu (hfc),. For the compounds studied, the S ...