A practical selective synthesis of mixed short/long chains glycerophosphocholines

P D'Arrigo, E Fasoli, G Pedrocchi-Fantoni…

Index: D'Arrigo, Paola; Fasoli, Ezio; Pedrocchi-Fantoni, Giuseppe; Rossi, Cristina; Saraceno, Caterina; Tessaro, Davide; Servi, Stefano Chemistry and Physics of Lipids, 2007 , vol. 147, # 2 p. 113 - 118

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Citation Number: 15

Abstract

Glycerophosphorylcholine (GPC) is transformed into the cyclic stannylene derivatives, which are selectively acylated to 1-acyl-2-lyso-glycerophosphocholines. The reaction is effective using C-2 to C-16 acid chlorides in 2-propanol. After solvent replacement the lyso- phospholipid (lyso-PL) is subjected to a second acylation using acid anhydrides in methylene chloride. A series of 1 (2)-short-2 (1)-long-diacyl-glycerophosphocholines are ...