Synthesis and anti-platelet activity of obovatol derivatives
…, NS Choi, H Lee, YP Yun, JT Hong, YS Kwak…
Index: Kwak, Jae-Hwan; Lee, Seul; Park, Eun-Seok; In, Jin-Kyung; Song, Jiho; Kim, Young Jin; Choi, Nam Song; Lee, Heesoon; Yun, Yeo-Pyo; Hong, Jin Tae; Kwak, Young-Shin; Min, Kyung Hoon; Jung, Jae-Kyung Archives of Pharmacal Research, 2011 , vol. 34, # 7 p. 1107 - 1112
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Citation Number: 4
Abstract
Abstract Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.
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