Synthesis, characterization and reactivity of copper (I) imidazole complexes based on a cavitand ligand design

…, KC Lam, AL Rheingold, CG Riordan

Index: Voo; Lam; Rheingold; Riordan Journal of the Chemical Society, Dalton Transactions, 2001 , # 12 p. 1803 - 1805

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Citation Number: 5

Abstract

Preorganization of metal binding residues is an important thermodynamic advantage achieved by proteins that insures kinetically robust active site compositions. The entatic state is the classic and most extreme case in which the polypeptide fold fixes ligand positions resulting in a metal ligation sphere distorted from the thermodynamic ground state structure. 1 The consequence of the distortion is a reduced activation barrier to electron transfer or to a chemical ...