Improved Procedure for the Preparation of 1-(2-Phenethyl)-4-piperidone

H Fakhraian, MBP Riseh

Index: Fakhraian; Panbeh Riseh, M. Babaei Organic Preparations and Procedures International, 2008 , vol. 40, # 3 p. 307 - 310

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Abstract

1-(2-Phenethyl)-4-piperidone (4) is a key intermediate for the preparation of fenranyl (analgesi~), I-~ its analogues6 and other medicaments.',* The most widely-used method for the synthesis of 4-piperidones is the Dieckmann cyclization of aminodicarboxylate esters which is a multi-steps procedure that occurs under equilibrium condition and is influenced by multiple parameters? The general method of McElvain for the preparation of 4- ...

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