An Efficient Synthesis of Mono and Bis??1, 2, 3??triazole AZT Derivatives via Copper (I)??catalyzed Cycloaddition

JW Yuan, LB Qu, XL Chen, ZB Qu…

Index: Yuan, Jin-Wei; Qu, Ling-Bo; Chen, Xiao-Lan; Qu, Zhi-Bo; Liu, Xiang-Qian; Ke, Dian-Dian Journal of the Chinese Chemical Society, 2011 , vol. 58, # 1 p. 24 - 30

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Citation Number: 2

Abstract

Abstract An efficient synthesis of novel mono and bis-1, 2, 3-triazoles 3′-azido-2′- deoxythymidine (AZT) derivatives via copper (I)-catalyzed 1, 3-dipolar cycloaddition reaction is described. Starting from AZT and terminal alkyne derivatives, mono and bis-1, 2, 3-triazole AZT derivatives are regioselectively obtained in good yields under mild conditions using CuSO4· 5H2O and sodium ascorbate as a catalyst system, and t-BuOH/H 2 O (1: 1, v/v) as ...