Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors

O Chahrour, A Abdalla, F Lam, C Midgley…

Index: Chahrour, Osama; Abdalla, Ashraf; Lam, Frankie; Midgley, Carol; Wang, Shudong Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 3066 - 3069

Full Text: HTML

Citation Number: 8

Abstract

Abstract We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N- phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.