Tetrahedron Letters

Total synthesis of aspinolide B: a ring-closing metathesis approach

S Ghosh, RV Rao

Index: Ghosh, Subhash; Rao, R. Vengal Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6937 - 6940

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Citation Number: 15

Abstract

A highly convergent stereoselective total synthesis of aspinolide B, a 10-membered lactone is described. The key step includes a ring-closing metathesis reaction to construct the 10- membered ring and the E—olefinic moiety. d-Mannitol was used as a chiral pool material for