Medium ring heterocycles: transamidation reactions of β-lactams
…, RCF Jones, S Osborne, AR Mat-Zin
Index: Crombie, Leslie; Jones, Raymond C. F.; Osborne, Steven; Mat-Zin, Ab. Rasid Journal of the Chemical Society, Chemical Communications, 1983 , # 17 p. 959 - 960
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Citation Number: 13
Abstract
Seven-, eight-, and nine-membered azalactams are easily prepared from azetidin-2-ones by transamidation via N- (halogenoalkyl) derivatives. ... The problem of constructing medium-ring saturated hetero- cycles has long exercised synthetic chemists. We have been interested in the possibility of using the strain energy of the four-membered ring, and in particular of the azetidin-2-one (p-lactam) system, as the driving force for ring expansion to medium rings. ...
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