Tetrahedron Letters

Facile synthesis of (+)-biotin via Fukuyama coupling reaction

T Shimizu, M Seki

Index: Shimizu, Toshiaki; Seki, Masahiko Tetrahedron Letters, 2000 , vol. 41, # 26 p. 5099 - 5101

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Citation Number: 38

Abstract

(+)-Biotin 1 has received considerable attention as an important vitamin for human nutrition and animal health. 1 Since the first total synthesis of (+)-biotin was accomplished about 50 years ago, a number of synthetic methods have been developed. 2 Among them, a method utilizing thiolactone 2 as a key intermediate has been one of the most reliable approaches so far developed. 3 The method is, however, not entirely satisfactory because a number of steps ...