Journal of heterocyclic chemistry

A facile and novel synthesis of 1, 6??naphthyridin??2 (1H)??ones

B Singh, GY Lesher

Index: Singh, Baldev; Lesher, George Y. Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2085 - 2091

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Citation Number: 31

Abstract

Abstract A new and convenient procedure for the synthesis of 1, 6-naphthyridin-2 (1H)-ones and their derivatives is described. In the first scheme 5-acetyl-6-[2-(dimethylamino) ethenyl]- 1, 2-dihydro-2-oxo-3-pyridinecarbonitrile (4) obtained by the reaction of N, N- dimethylformamide dimethyl acetal with 5-acetyl-1, 2-dihydro-6-methyl-2-oxo-3- pyridinecarbonitrile (3) was cyclized to 1, 2-dihydro-5-methyl-2-oxo-1, 6-naphthyridine-3- ...