Synthesis and structure-activity relationships of cetiedil analogues as blockers of the Ca2+-activated K+ permeability of erythrocytes

…, M Malik-Hall, DG Haylett, DH Jenkinson

Index: Roxburgh; Ganellin; Athmani; Bisi; Quaglia; Benton; Shiner; Malik-Hall; Haylett; Jenkinson Journal of Medicinal Chemistry, 2001 , vol. 44, # 20 p. 3244 - 3253

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Citation Number: 16

Abstract

Cetiedil,[2-cyclohexyl-2-(3-thienyl) ethanoic acid 2-(hexahydro-1 H-azepin-1-yl) ethyl ester], which blocks the intermediate calcium-activated potassium ion permeability (IKCa) in red blood cells, was used as a lead for investigating structure-activity relationships with the aim of determining the pharmacophore and of synthesizing agents of greater potency. A series of compounds having structures related to cetiedil was made and tested on rabbit ...