Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity

…, RR Wang, J Sun, JJ Dong, QR Du, F Fang…

Index: Li, Jing-Ran; Li, Dong-Dong; Wang, Rong-Rong; Sun, Jian; Dong, Jing-Jun; Du, Qian-Ru; Fang, Fei; Zhang, Wei-Ming; Zhu, Hai-Liang European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 438 - 447

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Citation Number: 11

Abstract

Abstract Components of fatty acid biosynthetic pathway have been identified as attractive targets for the development of new antibacterial agents. Compounds of series A (4a–4g) and series B (5a–5g) were synthesized by the formation of an amine bond between aromatic acid and 4-phenylthiazol-2-amine or 4-(4-bromophenyl) thiazol-2-amine. These thiazole derivatives have evaluated as potent FabH inhibitors. Nineteen compounds (4b–4h, 4k, 4l, ...