t-Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1

GW Anderson, FM Callahan

Index: Anderson,G.W.; Callahan,F.M. Journal of the American Chemical Society, 1960 , vol. 82, p. 3359 - 3363

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Citation Number: 236

Abstract

The synthesis of t-but)-1 esters of amino acids and peptides and their use in peptide synthesis is described. The most convenient method was the acid-catalyzed reaction of isobutylene with benzyloxycarbonylamino acids or peptides followed by catalytic hydrogenation to produce the basic esters. Another general method entailed the use of silver salts and t-butyl iodide. &Butyl esters are particularly useful in peptide synthesis in ...