Rhizoxin synthetic studies. 2. Synthesis of the left hand [C (10) to C (19)] and polyene fragments
DP Provencal, C Gardelli, JA Lafontaine, JW Leahy
Index: Provencal, David P.; Gardelli, Cristina; Lafontaine, Jennifer A.; Leahy, James W. Tetrahedron Letters, 1995 , vol. 36, # 34 p. 6033 - 6036
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Citation Number: 37
Abstract
The syntheses of the central core and the polyene fragments of the antitumor macrolide rhizoxin have been achieved in an efficient manner. The core has been prepared in enantiopure form via an asymmetric allylation/aldol protocol. The selective oxidation of dienes was studied and realized in fair yield to generate the requisite aldol precursor. The oxazole polyene fragment was generated in six steps from serine.
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