Synthesis and antimicrobial activity of novel amphiphilic aromatic amino alcohols

…, PP de Castro, VL Silva, CG Diniz, M Le Hyaric

Index: De Almeida, Angelina M.; Nascimento, Thiago; Ferreira, Bianca S.; De Castro, Pedro P.; Silva, Vania L.; Diniz, Claudio G.; Le Hyaric, Mireille Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2883 - 2887

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Citation Number: 4

Abstract

We report in this work the preparation and in vitro antimicrobial evaluation of novel amphiphilic aromatic amino alcohols synthesized by reductive amination of 4- alkyloxybenzaldehyde with 2-amino-2-hydroxymethyl-propane-1, 3-diol. The antibacterial activity was determined against four standard strains (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa) and 21 clinical ...