A study of the delivery-targeting concept applied to antineoplasic drugs active on human osteosarcoma. I. Synthesis and biological activity in nude mice carrying …
…, O Fodstad, G Schwartsmann, HR Hendriks
Index: Sturtz; Appere; Breistol; Fodstad; Schwartsmann; Hendriks European Journal of Medicinal Chemistry, 1992 , vol. 27, # 8 p. 825 - 833
Full Text: HTML
Citation Number: 52
Abstract
Abstract With the aim of verifying the concept of osteotic vectorisation, synthesis of three methotrexate (MTX) gem-diphosphonic analogues (compounds A, B and C) was performed. These molecules were tested on BALB/c and NIH III mice previously grafted with subcutaneous implants of OHS, TTX p7 and/or TTX p11 human osteosarcoma cell lines. Antineoplasic activity of compound B and C (active compounds) was compared to the ...
Related Articles:
Synthesis of amino acid esters by papain
[Cantacuzene, D.; Pascal, F.; Guerreiro, C. Tetrahedron, 1987 , vol. 43, # 8 p. 1823 - 1826]
[Chemical communications (Cambridge, England), , # 19 p. 1908 - 1909]
[Justus Liebigs Annalen der Chemie, , vol. 673, p. 196 - 207]