A rapid esterification by means of mixed anhydride and its application to large-ring lactonization.

J Inanaga, K Hirata, H Saeki, T Katsuki…

Index: Inanaga,J. et al. Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 1989 - 1993

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Citation Number: 1924

Abstract

A rapid and mild esterification method using carboxylic 2, 4, 6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed. The method was also successfully applied to the synthesis of large-ring lactones, including DL-2, 4, 6-tridemethyl-3- deoxymethynolide.

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