Total synthesis of tautomycin
M Oikawa, T Ueno, H Oikawa…
Index: Oikawa, Masato; Ueno, Tohru; Oikawa, Hideaki; Ichihara, Akitami Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5048 - 5068
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Citation Number: 99
Abstract
A convergent stereocontrolled synthesis of the antifungal antibiotic tautomycin, a potent protein phosphatases inhibitor, has been achieved first via key aldol coupling of two large subunits, a righthand C1-CZ1 ketone and a left-hand aldehyde (left from CZZ). The Cl-ClO segment was synthesized through a remote stereochemical control process using a spiroketal template. After joining with the C11-Cls segment, the spiroketal moiety was ...
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