Synlett

N-Alkoxymethylation of carboxamides catalyzed by Brønsted acids

I Ledneczki, PM Agocs, A Molnar

Index: Ledneczki, Istvan; Agocs, Pal M.; Molnar, Arpad Synlett, 2003 , # 14 p. 2255 - 2257

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Citation Number: 5

Abstract

Abstract The reaction of carboxamides and dialkoxymethanes can be affected by sulfonic acids (methanesulfonic acid, p-toluenesulfonic acid, and Nafion-H SAC-13 silica nanocomposite) to yield N-alkoxymethylcarboxamides. Various types of N-alkyl-and N-aryl- substituted acetamides can be reacted in a one-step procedure to give the products in moderate to good yields.