SAR Studies of 3-Cyclopropanecarbonyloxy-2-cyclohexen-1-one as Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase
…, CS Wu, SW Lin, JL Huang, YS Sun, DY Yang
Index: Lin, Yung-Lung; Wu, Chung-Shieh; Lin, Shean-Woei; Huang, Jian-Lin; Sun, Yang-Sheng; Yang, Ding-Yah Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 3 p. 685 - 690
Full Text: HTML
Citation Number: 19
Abstract
Various 3-cyclopropanecarbonyloxy-2-cyclohexen-1-one 1 derivatives have been synthesized and tested as inhibitors of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) from pig liver. The inhibition results indicated that well-positioned dicarbonyl groups as well as the cyclopropyl group of 1 were essential for potent inhibition. Substitution at the 2- position of the ring system has a significant effect on inhibitor potency, while the 5-position ...
Related Articles:
[Kumar, Rakesh; Sharma, Prabha; Shard, Amit; Tewary, Dhananjay Kumar; Nadda, Gireesh; Sinha, Arun Kumar Medicinal Chemistry Research, 2012 , vol. 21, # 6 p. 922 - 931]
[Kumar, Rakesh; Mohanakrishnan, Dinesh; Sharma, Abhishek; Kaushik, Naveen Kumar; Kalia, Kalpana; Sinha, Arun Kumar; Sahal, Dinkar European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 5292 - 5301]
[Sinha, Arun K.; Joshi, Bhupendra P.; Acharya, Ruchi Chemistry Letters, 2003 , vol. 32, # 8 p. 780 - 781]
Synthesis and electronic absorption and fluorescence of 2-arylbenzothiazole derivatives
[Chen, Lianqing; Yang, Chuluo; Li, Suyue; Qin, Jingui Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 2 p. 317 - 322]
Synthesis and electronic absorption and fluorescence of 2-arylbenzothiazole derivatives
[Chen, Lianqing; Yang, Chuluo; Li, Suyue; Qin, Jingui Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2007 , vol. 68, # 2 p. 317 - 322]