N-Morpholino-and N-diethyl-analogues of palmitoylethanolamide increase the sensitivity of transfected human vanilloid receptors to activation by anandamide without …

…, DM Lambert, D Smart, KO Jonsson, CJ Fowler

Index: Vandevoorde, Severine; Lambert, Didier M.; Smart, Darren; Jonsson, Kent-Olov; Fowler, Christopher J. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 6 p. 817 - 825

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Citation Number: 11

Abstract

The abilities of 19 analogues of palmitoylethanolamide and two analogues of oleoylethanolamide to affect the Ca2+ influx into human embryonic kidney cells expressing the human vanilloid receptor (hVR1-HEK293 cells) in response to anandamide (AEA) have been investigated using a FLIPR assay and a bovine serum albumin-containing assay medium. Only palmitoylethanolamide produced any effect in the absence of AEA. The ...