Trifluoromethanesulfonic acid: a novel solvent for the electrophilic fluorination of fluoroaromatics

PL Coe, AM Stuart, DJ Moody

Index: Coe, Paul L.; Stuart, Alison M.; Moody, David J. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 11 p. 1807 - 1811

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Abstract

Trifluoromethanesulfonic acid has been discovered to be an excellent new solvent for promoting the direct elemental fluorination of aromatics. Fluorobenzene has been successfully fluorinated to a mixture of 1, 4-difluorobenzene (31%) and 1, 2-difluorobenzene (7%) in CFCl3–CF3SO3H (5%), but no further improvement is observed by the addition of boron trifluoride. When the reaction is carried out in only CFCl3, the main reaction ...