Cu-catalyzed regioselective carbomagnesiation of dienes and enynes with sec-and tert-alkyl Grignard reagents

H Todo, J Terao, H Watanabe, H Kuniyasu…

Index: Todo, Hirohisa; Terao, Jun; Watanabe, Hideyuki; Kuniyasu, Hitoshi; Kambe, Nobuaki Chemical Communications, 2008 , # 11 p. 1332 - 1334

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Abstract

The addition of Grignard reagents across carbon–carbon multiple bonds (carbomagnesiation) is a principal and important reaction in organic syntheses for the generation of Grignard reagents with the complicated structure of carbon skeletons. 1 It is known that methyl, aryl, allyl, and primary-alkyl Grignard reagents efficiently undergo carbomagnesiation and form diverse unsaturated hydrocarbons such as alkenes, alkynes, and dienes in the ...