Synthesis and antiallergic activities of 1, 3-oxazolo [4, 5-h] quinolines

JH Musser, H Jones, S Sciortino, K Bailey…

Index: Musser, John H.; Jones, Howard; Sciortino, Stanley; Bailey, Kevin; Coutts, Stephen M.; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1255 - 1259

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Citation Number: 18

Abstract

A series of new 1, 3-oxazolo [4, 5-h] quinolines has been prepared. These compounds were tested as inhibitors of antigen-induced release of histamine (AIR) in vitro from rat peritoneal mast cells (RMC) and as inhibitors of IgE-mediated passive cutaneous anaphylaxis in the rat (PCA). After several modifications of the original lead, the most potent compound of the series was determined to be 5-chloro-l, 3-oxazolo [4, 5-h] quinoline-2-carboxylic acid ...