Synthesis of Pyrimidine??Containing Nucleoside β??(R/S)??Hydroxyphosphonate Analogues

M Meurillon, L Chaloin, C Périgaud…

Index: Meurillon, Maia; Chaloin, Laurent; Perigaud, Christian; Peyrottes, Suzanne European Journal of Organic Chemistry, 2011 , # 20-21 p. 3794 - 3802

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Abstract

Abstract A concise route to nucleoside β-hydroxyphosphonate analogues is described. The use of a nucleoside β-ketophosphonate as the key intermediate allowed both the (R) and (S) isomers of β-hydroxyphosphonate analogues in the pyrimidine series to be accessed. Such derivatives may be considered as stable mimics of 5′-monophosphate nucleosides and, therefore, could be the starting point for the development of potential therapeutic agents.

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