Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents

…, ZQ Wang, XM Wang, Y Hui, Y Ling, XY Wang…

Index: Xiao, You-An; Wang, Zhi-Qiang; Wang, Xue-Min; Hui, Yi; Ling, Yong; Wang, Xin-Yang; He, Li-Qin Chinese Chemical Letters, 2013 , vol. 24, # 8 p. 727 - 730

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Citation Number: 4

Abstract

Novel 2-aminoimidazolone derivatives were synthesized. Most compounds displayed strong anticancer activities against human carcinoma cells in vitro. Compounds 8a, 8b and 8j exhibited optimal activity superior to 5-FU in most cancer cells tested. Especially, the IC50s of 8b (12.6–21.5 μmol/L) against five tumor cells were 1–4 fold less than those of 5-FU (18.4– 56.1 μmol/L) in vitro. Furthermore, compound 8b could induce SMMC-7721 cell apoptosis ...