Tetrahedron letters

Preparation of polyfunctional nitriles by the cyanation of functionalized organozinc halides with p-toluenesulfonyl cyanide

I Klement, K Lennick, CE Tucker, P Knochel

Index: Klement, Ingo; Lennick, Klaus; Tucker, Charles E.; Knochel, Paul Tetrahedron Letters, 1993 , vol. 34, # 29 p. 4623 - 4626

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Citation Number: 73

Abstract

Abstract Various alkyl, alkenyl, akynyl, benzylic, aromatic or heterocyclic organozinc halides bearing functional groups such as an ester, a boronic ester, a cyanide, a halide or a trialkoxysilyl group react under mild conditions with p-toluenesulfonyl cyanide affording polyfunctional nitriles in 69–93% yields.

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