Catalytic asymmetric glyoxylate-ene reaction: a practical access to. alpha.-hydroxy esters in high enantiomeric purities

K Mikami, M Terada, T Nakai

Index: Mikami, Koichi; Terada, Masahiro; Nakai, Takeshi Journal of the American Chemical Society, 1990 , vol. 112, # 10 p. 3949 - 3954

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Citation Number: 331

Abstract

Abstract: An efficient asymmetric catalysis is developed for the glyoxylate-ene reaction to afford the a-hydroxy esters of biological and synthetic importance. The key to the success is the use of the chiral titanium complex prepared in situ from (i-Pr0) 2TiX2 (X= CI or Br) and the (R)-or (S)-binaphthol in the presence of molecular sieves (MS 4A). The presence of the molecular sieves (zeolite) is clarified to facilitate the alkoxy-ligand exchange reaction. ...