Enantioselective friedel-crafts alkylations catalyzed by bis (oxazolinyl) pyridine-scandium (III) triflate complexes

…, KR Fandrick, HJ Song, KA Scheidt, R Xu

Index: Evans, David A.; Fandrick, Keith R.; Song, Hyun-Ji; Scheidt, Karl A.; Xu, Risheng Journal of the American Chemical Society, 2007 , vol. 129, # 32 p. 10029 - 10041

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Citation Number: 192

Abstract

The enantioselective Friedel-Crafts addition of a variety of indoles catalyzed by bis (oxazolinyl) pyridine-scandium (III) triflate complexes (Sc (III)-pybox) was accomplished utilizing a series of β-substituted α, β-unsaturated phosphonates and α, β-unsaturated 2-acyl imidazoles. The acyl phosphonate products were efficiently transformed into esters and amides, whereas the acyl imidazole adducts were converted to a broader spectrum of ...