Diamine preparation for synthesis of a water soluble Ni (II) salen complex
JM Shearer, SE Rokita
Index: Shearer, Jason M.; Rokita, Steven E. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 3 p. 501 - 504
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Citation Number: 17
Abstract
A reliable and efficient synthesis of NiNi (II) salen complex useful in probing nucleic acid structure is described and illustrates a general approach for constructing cis diamines suitable for assembly into N2O2 Schiff base complexes. Two equivalents of an aryllithium reacted with 1, 4-dimethylpiperazine-2, 3-dione to form the symmetric α-dione. This material was then converted to its dioxime and reduced by TiCl4/NaBH4 to yield the meso-diamine ...
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