Synthesis of 1-Hydroxyalkyl-3-Substituted Ureas and Thioureas, Substrates for Alcohol Dehydrogenase

ON Leonov, VM Shcherbakov, VM Devichensky…

Index: Leonov; Shcherbakov; Devichensky; Kryukova; Vorontsov; Kuznetsov; Kryukov Russian Journal of Bioorganic Chemistry, 2001 , vol. 27, # 3 p. 191 - 194

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Abstract

1 INTRODUCTION Despite the medical achievements in the treatment of chronic alcoholism, the assortment of medicines for its correction is limited [1, 2]. 2 Therefore, the search for the compounds affecting the ethanol biotransformation remains topical. In this work, 1-hydroxyalkyl-3-substituted ureas and thioureas, which contain a primary hydroxyl group and structurally resemble the drug disulfiram (teturamin) [2, 3], became the subjects under study.