Chinese Chemical Letters

Tetrazole-1-acetic acid as a ligand for copper-catalyzed N-arylation of imidazoles with aryl iodides under mild conditions

FT Wu, P Liu, XW Ma, JW Xie, B Dai

Index: Wu, Feng-Tian; Liu, Ping; Ma, Xiao-Wei; Xie, Jian-Wei; Dai, Bin Chinese Chemical Letters, 2013 , vol. 24, # 10 p. 893 - 896

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Citation Number: 14

Abstract

Abstract Tetrazole-1-acetic acid was found to serve as a superior ligand for CuI-catalyzed N- arylation of imidazoles with aryl iodides under a low catalyst loading (5 mol% of CuI). A variety of aryl iodides could be aminated to provide the N-arylated products in good to excellent yields without the need of an inert atmosphere.