Isotope effects on hydride transfer between NAD+ analogs

…, RMG Roberts, MM Kreevoy

Index: Ostovic, Drazen; Roberts, Roger M. G.; Kreevoy, Mourice M. Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7629 - 7631

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Citation Number: 66

Abstract

Abstract: Primary kinetic hydrogen isotope effects (KIE's) for hydride transfer between NAD'analogues are between 6 and 4, for reactions with equlibrium constants ranging from 0.7 to 10l6. There is no sign of the sharp change in KIE which would signal the change of a rate-limiting step in a multistep mechanism, and other evidence also indicates a one-step mechanism. 2 The secondary KIE produced by changing the hydrogen already attached ...