Structure determination and synthesis of fluoro nissl green: An RNA-binding fluorochrome

CA Merlic, S Motamed, B Quinn

Index: Merlic, Craig A.; Motamed, Soheil; Quinn, Bruce Journal of Organic Chemistry, 1995 , vol. 60, # 11 p. 3365 - 3369

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Citation Number: 78

Abstract

The isolation, structure determination, and total synthesis of Fluoro Nissl Green, a novel RNA-binding fluorochrome, are reported. Initially obtained in only one part per lo5, via a microwaveinduced synthesis from m-phenylenediamine, the structure was determined by spectroscopic methods to be 3, 8-diamino-lOH-quindoline. The proposed structure was confirmed by a rational synthesis starting from m-phenylenediamine and 2, 4- ...