Crystallography, quantitative structure-activity relationships,(QSAR) and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from …

C Hansch, BA Hathaway, Z Guo…

Index: Hansch; Hathaway; Guo; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 129 - 143

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Citation Number: 55

Abstract

+ 1)-0.90~+ 0.691+ 4.67. In the L. casei equation, I is an indicator variable for substituents of the type CH2ZC6H4-Y and ZCH, CsH4-Y, where Z= 0, NH, S, or Se. The parameter v is Charton's steric parameter, which is similar to Taft's E,. The mathematical models obtained from correlation analysis are compared with stereo color graphics models.