Synthesis of novel symmetrical, single-chain, diacetylene-modified bolaamphiphiles with different alkyl chain lengths
S Drescher, K Helmis, A Langner, B Dobner
Index: Drescher, Simon; Helmis, Katrin; Langner, Andreas; Dobner, Bodo Monatshefte fur Chemie, 2010 , vol. 141, # 3 p. 339 - 349
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Citation Number: 7
Abstract
Abstract General syntheses of novel symmetrical, single-chain, diacetylene-modified bolaphospholipids have been carried out in five steps. For the ω-alkynols, which have an important role as key intermediates, three different synthetic approaches were comprehensively investigated. For the final synthesis it is suggested that (1) alkylation of lithium (trimethylsilyl) acetylide with tetrahydropyranyl-protected ω-bromoalcohols, ...
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