Tricyclic neuroleptics: Synthesis of metabolites of isofloxythepin and some related compounds

…, J Jílek, J Pomykáček, V Valenta…

Index: Sindelar, Karel; Jilek, Jiri; Pomykacek, Josef; Valenta, Vladimir; Hrubantova, Marta; et al. Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 9 p. 2282 - 2303

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Abstract

Abstract The isofloxythepin (I) metabolite IV was synthesized via the acids IX and XI and the esters X and XII. The enamine VIII was prepared from 3-fluoro-8-(2-propyl) dibenzo [b, f] thiepin-10 (11H)-one by two methods and was reduced to I. Cloflumide (II) was obtained by reaction of 2, 10-dichloro-7-fluoro-10, 11-dihydrodibenzo [b, f] thiepin with 3-(1-piperazinyl) propionamide and was oxidized to the sulfoxide XVI. The unsaturated analogue XVII of ...