A new series of photoactivatable and iodinatable linear vasopressin antagonists

E Carnazzi, A Aumelas, C Barberis…

Index: Carnazzi; Aumelas; Barberis; Guillon; Seyer Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1841 - 1849

Full Text: HTML

Citation Number: 23

Abstract

A series of new linear photoactivatable and iodinatable antagonists of the neuropeptidic hormone vasopressin was designed and synthesized by a combination of PyBOP-mediated Boc/solid-phase peptide synthesis and solution synthesis approaches. These were based on modifications of a previously reported potent and selective antagonist of the vasopressor response (VI, receptor) to [argininelvasopressin, phenylacetyl-~-Tyr (Me)-Phe-Gln-Asn- ...