Synthesis and evaluation of a novel series of N, N-dimethylisotryptamines

…, JM Jacyno, R Young, JD McKenney…

Index: Glennon; Jacyno; Young; McKenney; Nelson Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 41 - 45

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Citation Number: 28

Abstract

7 X= CH 9 X= N finity and abolishes behavioral activity but that replacement of the benzylic carbon atom of 2 with a nitrogen atom (ie, 3) or conversion of 2 to a somewhat more conformationally constrained molecule (ie, 5) both result in an enhancement of affinit~.~ Thus, it was of interest to prepare 6, the nitrogen counterpart of 5, as well as several related unsaturated derivatives of 6, ie, N, N-dimethylisotryptamines, 7. These compounds were ...