Practical synthesis of a potent bradykinin B1 antagonist via enantioselective hydrogenation of a pyridyl N-acyl enamide

PD O'Shea, D Gauvreau, F Gosselin…

Index: Journal of Organic Chemistry, , vol. 74, # 12 p. 4547 - 4553

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Citation Number: 18

Abstract

... The Journal of Organic Chemistry. ... J. Org. Chem. , 2009, 74 (12), pp 4547–4553. DOI: 10.1021/jo802772d. Publication Date (Web): May 20, 2009. Copyright © 2009 American Chemical Society. paul_oshea@merck.com, † Merck Frosst Centre for Therapeutic Research. , ‡ ...