Novel Qualitative Structure-Activity Relationships for the Antinociceptive Actions of H2 Antagonists, H3Antagonists and Derivatives

…, H Timmerman, ME Carlile, C Cioffi, M Wentland

Index: Hough; Nalwalk; Li; Leurs; Menge; Timmerman; Carlile; Cioffi; Wentland Journal of Pharmacology and Experimental Therapeutics, 1997 , vol. 283, # 3 p. 1534 - 1543

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Citation Number: 34

Abstract

Abstract Recent studies have shown that cimetidine, burimamide and improgan (also known as SKF92374, a cimetidine congener lacking H 2 antagonist activity) induce antinociception after intracerebroventricular administration in rodents. Because these substances closely resemble the structure of histamine (a known mediator of some endogenous analgesic responses), yet no role for known histamine receptors has been found in the analgesic ...