Synthesis of 3, 6-bis (aminoalkoxy) acridines and their effect on the immune system

RB Angier, RV Citarella, M Damiani…

Index: Angier, Robert B.; Citarella, Ronald V.; Damiani, Martin; Fabio, Paul F.; Fields, Thomas L.; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1710 - 1715

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Citation Number: 11

Abstract

A series of 3, 6-bis (aminoalkoxy) acridines (2) was prepared and shown to have a protective antiviral effect against an interferon-sensitive virus (Columbia SK) and to partially restore an antibody response to a T-cell-dependent antigen in leukemic immunosuppressed mice. The presence of circuIating interferon and the stimulation of natural killer cell activity in mice was observed for 21.