Regiocontrolled synthesis and HIV inhibitory activity of unsymmetrical binaphthoquinone and trimeric naphthoquinone derivatives of conocurvone
…, HC Malinakova, B Twenter, M Yu, LE Holland…
Index: Stagliano, Kenneth W.; Emadi, Ashkan; Lu, Zhenhai; Malinakova, Helena C.; Twenter, Barry; Yu, Min; Holland, Louis E.; Rom, Amanda M.; Harwood, John S.; Amin, Ronak; Johnson, Allison A.; Pommier, Yves Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5651 - 5665
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Citation Number: 34
Abstract
Unsymmetrical biquinone and trimeric quinone derivatives were synthesized using halotriflate-biselectrophilic naphthoquinones through stepwise regioselective quinone substitution chemistry and evaluated for their ability to inhibit the cytopathogenic effects of HIV-1 using an MTT colorimetric assay. Compounds were also screened for their ability to inhibit the activity of HIV-1 integrase in vitro. Pyranylated trimeric quinones and ...
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