Practically Perfect Asymmetric Autocatalysis with (2??Alkynyl??5??pyrimidyl) alkanols

T Shibata, S Yonekubo, K Soai

Index: Shibata; Yonekubo; Soai Angewandte Chemie - International Edition, 1999 , vol. 38, # 5 p. 659 - 661

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Citation Number: 119

Abstract

Abstract Extremely high enantioselectivity (> 99.5% ee) and chemical yield (> 99%) are achieved in an asymmetric autocatalytic reaction. A (5-pyrimidyl) alkanol with a tert- butylethynyl group at its 2-position (1) is a very efficient asymmetric autocatalyst in the enantioselective alkylation in Equation (1).