Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity

M Arisawa, Y Kasaya, T Obata, T Sasaki…

Index: Chen, Bang-Chi; Hynes Jr., John; Pandit, Chennagiri R.; Zhao, Rulin; Skoumbourdis, Amanda P.; Wu, Hong; Sundeen, Joseph E.; Leftheris, Katerina Heterocycles, 2001 , vol. 55, # 5 p. 951 - 960

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Citation Number: 14

Abstract

... When the substituent at the 7-position (R 1 ) is bulkier than that at the 2-position (R 2 ), the s ... 2-vinylaniline derivatives by a one-pot isomerization/enamide-ene metathesis and subsequent removal of p-toluenesulfonyl group ... (e) 4-ClC 6 H 4 COCl, tBuOK, THF, −78 °C, 71–95%. ...