Tetrahydrochromenoimidazoles as Potassium-Competitive Acid Blockers (P-CABs): Structure− Activity Relationship of Their Antisecretory Properties and Their Affinity …

…, PJ Zimmermann, C Brehm, W Buhr…

Index: Palmer, Andreas Marc; Muench, Gabriela; Brehm, Christof; Zimmermann, Peter Jan; Buhr, Wilm; Feth, Martin Philipp; Simon, Wolfgang Alexander Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1511 - 1530

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Citation Number: 15

Abstract

Potassium-competitive acid blockers (P-CABs) constitute a new therapeutic option for the treatment of acid-related diseases that are widespread and constitute a significant economical burden. Enantiomerically pure tetrahydrochromenoimidazoles were prepared using the readily available candidate 4 (BYK 405879) as starting material or the Noyori asymmetric reduction of ketones as key reaction. A comprehensive SAR regarding the ...