Total synthesis of amphotericin B

KC Nicolaou, RA Daines, TK Chakraborty…

Index: Nicolaou, K. C.; Daines, R. A.; Chakraborty, T. K.; Ogawa, Y. Journal of the American Chemical Society, 1987 , vol. 109, # 9 p. 2821 - 2822

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Citation Number: 60

Abstract

OH" 2 amphotericin B (1) 3-5 in its naturally occurring enantiomeric form. The thorny nature of an eventual total synthesis of this complex and widely used antibiotic has long been recognized, particularly in view of the glycosidation step. Justified concerns stemmed from (a) the rather labile nature of amphoteronolide B6 and arnphotericin B (1) and their derivatives,(b) the presence of a basic nitrogen in the carbohydrate moiety, and (c) the ...