Synthesis of 2, 4-disubstituted thiazoles and selenazoles as potential antitumor and antifilarial agents. 1. Methyl 4-(isothiocyanatomethyl) thiazole-2-carbamates,- …

Y Kumar, R Green, KZ Borysko, DS Wise…

Index: Kumar; Green; Borysko; Wise; Wotring; Townsend Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3843 - 3848

Full Text: HTML

Citation Number: 138

Abstract

Methyl 4-(isothiocyanatomethy1) thiazole-2-carbamate and methyl 4-(isothiocyanatomethyl) sel-enazole-2-carbamate have been prepared via chemical transformations involving 2- amino-4-(chloromethy1) thiazole (1) and 2-amino-4-(chloromethyl) selenazole (2), respectively, as starting materials. The homoanalog, methyl 4-(2-isothiocyanatoethyl) thiazole-2-carbamate, was prepared from (2-aminothiazol-4-y1) acetic acid. All ...